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Tropharma 500mg 20 tabs, Erythromycin

INDICATIONS: Mild to moderate infections of the upper and lower respiratory tract, skin and subcutaneous tissues.

Can be used in conjunction with appropriate doses sulfonamides treating mild to moderate infections of the upper respiratory tract because not all strains are susceptible to erythromycin concentration usually obtained in serum.

Erythromycin is an alternative drug that can be used for the treatment of primary syphilis in patients allergic to penicillin.

Human Pharmacokinetics: Erythromycin inhibits protein synthesis without affecting nucleic acid synthesis. This inhibition is effected by reversible binding of the drug to the 50s ribosomal subunit.

From macrolide-sensitive microorganisms, gram positive bacteria accumulate 100 times the gram negative erythromycin. Some strains of H. influenzae that are resistant to erythromycin in vitro alone are susceptible to it when combined with sulfonamides.

Stearate orally rapidly absorbed. Stability in acidic media allows the serum concentrations are similar once ingested either before or after meals.

After oral administration, blood concentrations of antibiotic achieved (30, 12 and 1.2 mg / h) at 2, 4 and 6 hours, respectively, and increased according to the dose, distributed in most fluids body except the cerebrospinal fluid.

Metabolized and is concentrated in the liver and is excreted in the bile. Approximately 5% is excreted in the urine as active. Erythromycin crosses the placental barrier, but its concentration in the fetus is low.

Hypersensitivity to erythromycin and the components of the formula. Pre-existing liver disease.

RESTRICTIONS OF USE DURING PREGNANCY AND LACTATION: No evidence of its safety during these periods so it is not recommended for use unless absolutely necessary and under the responsibility of the physician.

ADVERSE REACTIONS: Occasionally colic and abdominal discomfort, nausea, vomiting, anaphylaxis, in renal or hepatic impairment have been isolated reports of reversible hearing loss and tinnitus, jaundice.

DRUG INTERACTIONS AND OTHER GENDER: Probenecid inhibits tubular reabsorption of erythromycin thereby increasing plasma concentrations.

Erythromycin and lincomycin or clindamycin should be avoided in the treatment of infections due to microorganisms resistant to erythromycin.

The use of erythromycin in patients receiving high doses of theophylline may be accompanied by an increase in serum theophylline and theophylline possibility that toxicity occurs. It is recommended to adjust the dose of theophylline.

Concomitant administration of erythromycin and digoxin may increase digoxin levels in serum. There have been reports of increased anticoagulant effects when erythromycin and its used oral anticoagulants concomitantly.

Concurrent use of erythromycin and ergotamine or dihydroergotamine has been associated in some patients with acute ergot toxicity (ergotism) characterized by peripheral vasospasm and dysesthesia. Erythromycin reduces debugging midazolam and triazolam and thus may increase the pharmacological effect of these benzodiazepines.

The use of erythromycin in patients who are concurrently taking drugs metabolized by cytochrome P-450 may be associated with elevations in serum.

CHANGES IN RESULTS OF LABORATORY TESTS have been published evidence indicating elevated serum AST and ALT in patients receiving erythromycin, however, does not reflect changes in liver function.

PRECAUTIONS IN RELATION TO EFFECTS Carcinogenesis, Mutagenesis, Impairment of Fertility: There have been studies of reproduction in rats, mice and rabbits using erythromycin and its various salts and these doses many times the usual human dose. No reported evidence of impaired fertility or harm to the fetus appears to be related to erythromycin in these studies.

However, no adequate and well controlled studies in pregnant women, because animal reproduction studies are not always used to predict human response.

This medicine should not be used during pregnancy unless clearly necessary.

MANIFESTATIONS AND MANAGEMENT OF OVERDOSE OR ACCIDENTAL INGESTION: Symptoms of oral erythromycin overdose may include nausea, vomiting, epigastric distress and diarrhea dose related. Acute pancreatitis has been reported, mild and reversible hearing loss can occur with or without tinnitus and dizziness, especially in patients with renal or hepatic impairment.

Treatment: gastric lavage is not necessary unless you have eaten 5 times the normal single dose.

Protect the patient's airway ventilation maintaining, monitoring of vital signs, blood gases, serum electrolytes, etc..

Drug absorption from the gastrointestinal tract may be decreased by giving activated charcoal, sometimes, is more effective than emesis.

Not established the benefit of forced diuresis, peritoneal dialysis, hemodialysis, or charcoal hemoperfusion for erythromycin overdose.

DOSAGE AND ADMINISTRATION: Oral.

Adults: The usual dose of 250-500 mg every 6 hours, may be increased to 4 g or more per day, depending on the severity of the infection.

Children: Age, weight and severity of the infection are important factors in determining dosage. It is recommended to 30-50mg  kg per day, may be increased to twice.

PRESENTATIONS:

Bottle with 20 tablets of 500 mg.

Bottle of 8 tablets of 500 mg.

RECOMMENDED STORAGE: Store in cool, dry place. Keep the bottle tightly closed.

LEGENDS OF PROTECTION

Exclusively for medical literature. Keep out of reach of children. Its sale requires a prescription.
Its use can cause obstruction biliohepática.
Drug Name: Tropharma Dosage
Comparable drug patent: Ilosone
Active substance: Erythromycin
Presentation: Tablets
Concentration: 500 mg
Extended-release tablets: No
Laboratory ALPHARMA
Box of 20 Tablets
Made in Mexico