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Generic Feldene 20mg 100 tabs, Piroxicam

THERAPEUTIC INDICATIONS: Piroxicam is indicated in a wide variety of problems that require antiinflammatory therapy and / or analgesic, such as rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis (arthrosis, degenerative joint disease), ankylosing spondylitis, acute musculoskeletal disorders, gout acute or postoperative pain secondary to acute trauma, treatment of primary dysmenorrhea in patients over 12 years of age and as an adjunct for relief of acute inflammatory processes of the upper airway, taking into consideration its analgesic and antipyretic.

Contraindications Active peptic ulcer.

Piroxicam should not be used in patients with previously demonstrated hypersensitivity to the drug. There is a potential cross-sensitivity to aspirin and other NSAIDs. Piroxicam should not be administered to patients in whom aspirin and other NSAIDs have induced symptoms of asthma, nasal polyps, angioedema or urticaria.

CAUTIONS: It is reported a rare incidence of peptic ulcer, perforation, and fatal gastrointestinal bleeding in some cases related to piroxicam. The administration of the drug should be closely monitored in patients with a history of upper gastrointestinal tract disease.

On rare occasions, non-steroidal anti-inflammatory agents (NSAIDs) can cause interstitial nephritis, glomerulitis, papillary necrosis and nephrotic syndrome. NSAIDs inhibit the synthesis of renal prostaglandins, which play an important role in maintaining renal perfusion in patients whose renal blood flow and volume are reduced. In these patients, NSAIDs may precipitate overt renal failure, which typically is reversible to pretreatment levels, after suspending the administration of NSAIDs. Patients at greatest risk of this reaction are those with congestive heart failure, liver cirrhosis, nephrotic syndrome and overt renal disease. Should be monitored closely in these patients while receiving treatment with NSAIDs.

Given that there have been reports of ocular adverse events during treatment with NSAIDs, practice eye examination for patients who develop visual disturbances during treatment with piroxicam.

It must be remembered that NSAIDs are only symptomatic treatment when used to relieve pain and inflammation in acute inflammatory upper respiratory tract, so that should be considered to the patient an appropriate antimicrobial for such conditions.

Effects on ability to drive and use machines: The effect of piroxicam on the ability to drive or operate heavy machinery has not been studied.

RESTRICTIONS OF USE DURING PREGNANCY AND LACTATION:

Pregnancy: Although there is no evidence of teratogenic effects in experimental animal models is not recommended the use of piroxicam during pregnancy. Piroxicam inhibits the synthesis and release of prostaglandins by reversibly inhibiting the enzyme cyclooxygenase. This action, like what is acceptable for other NSAIDs, is associated with increased frequency of dystocia and delayed parturition in animals when the drug continued until the end of pregnancy. It is also known that NSAIDs induce closure of the ductus arteriosus in infants.

Lactation: It has been determined the presence of piroxicam in breast milk at baseline and after several days of administration (52 days). Showed the presence of piroxicam in breast milk in quantities of 1 to 3% of plasma concentrations in the mother during treatment. No accumulation of piroxicam appeared in milk to plasma ratio. Not recommended the use of piroxicam during lactation, because that has not established its clinical safety.