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Penprocilina 800,000u INJECTION SUSP, Benzylpenicillin Procaine
INDICATIONS: tonsillitis, pharyngitis, pneumonia, bronchopneumonia, bacterial endocarditis, bacterial meningitis, stomatitis, gonorrhea, syphilis and all those infections caused by susceptible bacteria.
Human Pharmacokinetics: Penicillin G is highly effective in vitro against many species (but not against all) of gram-negative and gram-positive cocci.
Among streptococci groups A, C, G, H, L and M are very susceptible, the groups B, E, F, K and N are moderately susceptible, enterococci are the least susceptible.
Gonococci are generally sensitive to penicillin G. The continued exposure of this organism to the antibiotic, has caused some decrease in sensitivity (Sparling, l972).
Absorption: For subcutaneous or intramuscular injection. The rate of absorption of penicillin G injected into the depth and persistence of blood levels achieved, depends on many factors including the dose, the vehicle, concentration, physical form and solubility of the salt or ester of penicillin G. The rapid absorption of soluble salts of penicillin, shows no significant difference after subcutaneous or intramuscular injection, it is preferred.
Other factors, especially renal excretion, influence the height and duration of antibiotic levels in plasma.
For example, is so rapid elimination of penicillin G by the kidneys, the plasma concentration drops to half its value at the end of an injected when an aqueous preparation.
Peak plasma levels are reached within 15-30 minutes. In most adults with diabetes mellitus, penicillin G level reached in the plasma after intramuscular injection is lower than in non-diabetic patients due to poor absorption.
Distribution: Penicillin G is diffused throughout the body, but there are marked differences in concentration in various liquids and tissues. Its apparent volume of distribution is approximately 50% of total body water.
Contraindications Penicillin is contraindicated in cases of hypersensitivity to penicillins and / or cephalosporins.
PRECAUTIONS: Penicillin should not be given to patients with history of allergy to penicillin, germs or infections resistant to penicillin.
Care should be taken not to administer medication or intravenous or intra-arterial, and avoid close or directly manage the level of the main peripheral nerves to avoid possible neurovascular damage.
RESTRICTIONS OF USE DURING PREGNANCY AND LACTATION: The use of penicillin during pregnancy and in the newborn is safe.
ADVERSE REACTIONS: As with all penicillins, allergic reactions can occur.
Allergic: Anaphylaxis, urticaria, bronchospasm, laryngeal edema, serum sickness, erythema nodosum, exfoliative dermatitis and maculopapular rash.
Gastrointestinal: Orally, glossitis, stomatitis, black tongue, vomiting, enterocolitis, pseudomembranous colitis, and diarrhea.
DRUG INTERACTIONS AND OTHER GENDER: The half-life of penicillin is increased with concurrent administration of probenecid. Penicillin inactive carbohydrate solutions at alkaline pH.
CHANGES IN RESULTS OF LABORATORY TESTS: None reported to date.
PRECAUTIONS IN RELATION TO EFFECTS Carcinogenesis, Mutagenesis, Impairment of Fertility: Penicillins cross the placenta. However, problems have not been described in humans. Currently no data on mutagenic and carcinogenic.
DOSAGE AND ADMINISTRATION:
Mild to moderate infections:
Children under 2 years: 200,000 U every 12 hours for 7-10 days.
Adults: 800,000 U every 12 hours for 7-10 days.
Severe infections:
Children under 2 years: 200,000 U every 8 to 12 hours for 7-10 days or as long as the doctor deems necessary.
Children 2 to 10 years: 400,000 U every 8 to 12 hours for 7-10 days or as long as the doctor deems necessary.
Adults: 800,000 U every 8-12 hours for at least 10 days, or as long as the doctor deems necessary.
It is recommended to continue treatment three days after remission of symptoms or fever.
After treatment, it is advisable to administer benzathine penicillin (Benzanil Benzanil single or compound) to extend the plasma levels of the antibiotic for longer.
MANIFESTATIONS AND MANAGEMENT OF OVERDOSE OR ACCIDENTAL INGESTION: No overdoses have been reported with Benzanil. Penicillins generally have minimal toxicity in man, however, the natural viscosity of suspensions of benzathine penicillin and procaine can cause any of the effects described in section neurovascular warnings, for which treatment should be symptomatic.
Drug Name: PENPROCILINA
Comparable drug patent: PENPROCILINA
Active substance: Benzylpenicillin Procaine / Benzylpenicillin
Presentation: SUSP. Injection
Concentration: 800,000 U
Extended-release tablets: No
Laboratory: Lakeside of Mexico
Made in: MEXICO
Box with vial with powder and diluent BULB
