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Lugaxil SUSP 800,000u INJ, Benzylpenicillin Procaine

INDICATIONS
Antiseptic and fungicide for external use. Antifungal and / or antibacterial surface dermatomycosis not extensive, infected forms of eczema, pyoderma and minor burns. Soothes and not burn. Helps heal and disinfect scrapes, cuts and minor burns. Aid relief of skin fungus.

Dosage form
Each vial contains:
                                                 U  800.000 400.000
Benzylpenicillin procaine
equivalent to 300,000 U 600.000 U
Benzylpenicillin

Crystalline benzylpenicillin
equivalent to 100.000 200.000 U U
Benzylpenicillin

The vial with diluent contains:
Water injection 2 ml 2 ml


INDICATIONS
LUGAXIL * is indicated for the treatment of cases of sore throat, upper respiratory tract infections, Vincent angina, scarlet fever, pneumonia, bronchopneumonia, erysipelas, infections of the skin and soft tissues, periodontitis, endocarditis, bacterial meningitis, syphilis, gonorrhea and in all the infections caused by bacteria sensitive to penicillin.


Pharmacokinetics
Benzylpenicillin develops a bactericidal effect by inhibiting cell wall synthesis in susceptible bacteria. Its main action spectrum are positive cocci, especially streptococci of groups A, B, C, G, H, L and M, pneumococci and penicillinase-producing staphylococci. The action of benzylpenicillin covers other sensitive microorganisms as Neisseria gonorrhoeae, Treponema pallidum, Clostridium, Actinomyces bovis, Bacillus anthracis, Corynebacterium diphtheriae, Listeria and Leptospira.

Crystalline Penicillin is absorbed rapidly from the injection site, obtaining serum between 15 and 30 minutes after administration. Procaine benzylpenicillin is released within 12 to 24 hours continuously from the injection site. Thus, the association of these penicillins allow to achieve rapid and sustained levels in blood and tissues.

About 60% of penicillin binds to plasma proteins with a wide distribution to tissues and body fluids. The eyes, and meninges penetration is limited, however, inflammation increases the amount of benzylpenicillin that crosses the blood brain barrier.

Penicillin is excreted in breast milk and is eliminated by glomerular filtration and tubular secretion by the kidney.


CONTRAINDICATIONS
Hypersensitivity to penicillin, interstitial nephritis, angioneurotic edema, serum sickness, anaphylactic shock.


PRECAUTIONS
During prolonged therapy with these drugs, you should undertake a periodic review of renal function, liver and blood count. Keep in mind the possibility of fungal or bacterial (Pseudomonas or Candida generated). If such an infection occurs, discontinue therapy and / or establish appropriate therapy.


RESTRICTIONS OF USE DURING PREGNANCY AND BREASTFEEDING
To date, no changes have been reported in humans during pregnancy. During lactation, no significant problems have been reported. However, because the penicillin is excreted in breast milk, this can lead to sensitization and skin rash in the infant.


ADVERSE REACTIONS
Like other antibiotics, penicillin can produce hypersensitivity reactions can range from skin rash, urticaria, erythema multiforme to anaphylaxis. May occur occasionally in hemolytic anemia, leukopenia, thrombocytopenia, neuropathy and nephropathy.


DRUG INTERACTIONS AND OTHER GENDER
When used concurrently with probenecid in the urinary excretion of penicillin it decreases, which causes serum levels remain high for longer.


CHANGES IN RESULTS OF LABORATORY TESTS
Determinations of glucose in urine may give false-positive or falsely elevated values ​​when the determination is made with copper sulfate (Benedict's or Fehling tests). This does not occur when the determinations are carried out with the enzyme method.


PRECAUTIONS IN RELATION TO EFFECTS Carcinogenesis, Mutagenesis, Impairment of Fertility
Caution should be used in people who have a history of allergies, especially to cephalosporins or other antibiotics. No reported abnormalities of carcinogenicity, mutagenicity, teratogenicity and fertility.


DOSAGE AND ADMINISTRATION
The recommended route of administration is intramuscular only.

The recommended doses are:

Children under 2 years: 200,000 U every 12 hours for 7-10 days.
Children 2 to 10 years: 400,000 U every 12 hours for 10 days.
Teens and adults: 800,000 U every 12 hours for 7-10 days.

The doctor will adjust the dose and frequency according to the requirements of each particular case.


MANIFESTATIONS AND MANAGEMENT OF OVERDOSE OR ACCIDENTAL INGESTION
The low toxicity of the penicillin allows for use in a wide range. No information has been reported related overdose.


PRESENTATIONS
Vial containing powder and 800,000 U 400.000 U and a vial with diluent.


STORAGE RECOMMENDATIONS
Store at room temperature to not more than 30 ° C and dry.
Drug Name: LUGAXIL
Comparable drug patent:
Active substance: Benzylpenicillin procaine / crystalline benzylpenicillin
Presentation: SUSP. Injection
Concentration: 600,000 U / 200,000 U
Prolonged release tablets: No
Laboratory BRULUAGSA
Made in: MEXICO