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Silogin 0.75mg 2 Tabs, Levonorgestrel

DOSAGE AND ADMINISTRATION: It is administered orally.
SILOGIN ® 0.75 mg 2 tablets: For optimal efficacy , the first tablet should be swallowed SILOGIN ® as soon as possible after unprotected intercourse , and no later than 72 hours ( 3 days) after thereof .
The second tablet must be ingested within 12 hours ( at the earliest) and 24 hours ( at the latest ) after the first shot as total dose.

If vomiting occurs within 2 hours after ingestion of the first or second tablet , you need to restart immediately take another dose or supplement , as applicable , as the gastric contents field could contain part or all medication for this reason , you will not get the effect desired therapeutic , always remembering that the total dose is 2 tablets. Antiemetic may be prescribed if necessary from the first shot.
SILOGIN® 1.5 mg 1 tablet : It should be noted as a single dose as soon as possible after unprotected intercourse , and no later than 72 hours (3 days) thereafter .
If vomiting occurs within the following single ingestion SILOGIN ® tablet 2 hours, taking an extra tablet to be indicated , the use of an antiemetic is recommended in these cases.
STORAGE RECOMMENDATIONS
Store at room temperature not exceeding 30 ° C.

CHANGES IN RESULTS OF LABORATORY TESTS : No reported .
Hypersensitivity to product components .
During lactation .
A
DVERSE REACTIONS :
They are reported as follows: Nausea , vomiting , headache, asthenia , dizziness, abdominal pain , a feeling of breast tenderness , adverse effects disappear spontaneously in 2-3 days bleeding metrorrhagia type ( any bleeding outside the expected period ) or isolated blood loss .

RESTRICTIONS OF USE DURING PREGNANCY AND BREASTFEEDING
Pregnancy: Levonorgestrel is not given under any circumstances if confirmed pregnancy .
Breastfeeding is not recommended during lactation . If necessary administration in this period , the woman should stop breastfeeding the baby for at least 5-7 days , replacing breast milk with formula.

Pharmacokinetics:
Pharmacokinetics norsteroid Levonorgestrel is a synthetic progestational activity with effective .
Levonorgestrel is a progestin that is rapidly absorbed in less than 1 hour, the maximum plasma concentration is reached in less than 2 hours.

The plasma protein binding of levonorgestrel plays an important role in pharmacokinetics , this union takes place both albumin and globulin sex hormone binding ( SHBG ) .
Levonorgestrel forms a stable long life with SHBG complex, this complex dissociates slowly.

Levonorgestrel is metabolized in the kidney ( 60 to 80% ) and liver (20-40%) , the half-life in plasma is 9 to 15 hours. It is eliminated by the kidney as glucuroconjugada .
Pharmacodynamics The mechanism of action of levonorgestrel is not completely understood .
SILOGIN ® in doses of two doses of 0.75 mg or a single dose of 1.5 mg blocks ovulation , preventing fertilization if intercourse has occurred in the 72 hours preceding ovulation , ie the period during which the risk fertilization is the highest.

It could also prevent implantation of an egg , but is ineffective if the process of implantation has begun.
Levonorgestrel is widely used for contraception , alone or in combination with estrogen , in combination , levonorgestrel is used at low concentration , whereas as contraceptive urgently required concentration is 1.5 mg , either in two doses of 0.75 mg each or dose only 1.5 mg .
Although the contraceptive efficacy of this drug is important, is not as high as other methods, emergency contraception reduces significantly the risk unwanted pregnancy .

Levonorgestrel when administered within 72 hours of unprotected sexual intercourse prevents about 85 % of pregnancies .
Levonorgestrel acts or levels at different times depending on the day of the cycle in which it is administered , interfering with sperm transport and penetration , follicular growth and development of the corpus luteum .
Two doses of 0.75 mg orally every 12 hours or 1.5 mg single dose between days 10-14 of the cycle, were effective to prevent implantation in a high percentage of women treated.

The results of clinical studies indicate that the effectiveness of levonorgestrel decreases in relation to the time since the unprotected (95 % at 24 hours , 85 % between 24 and 48 hours and 58 % between 48 and 72 hours) relationship . There are no reports of efficacy after 72 hours.
At doses above , levonorgestrel not induce significant changes in the coagulation and metabolism of carbohydrates and lipids .

Dosage form :
Each tablet contains:
Levonorgestrel 0.75 or 1.5 mg
Excipient c.b.p. 1 tablet .

INDICATIONS: Contraception emergency postcoital for use in the first 72 hours after unprotected sex .
The use of this medication is for women of reproductive age, including adolescents , in order to avoid an unwanted pregnancy. The contraceptive efficacy of this method of urgency is of the order of 85 %.
Emergency contraception in a time less than 72 hours after unprotected intercourse as rape or in case of failure or omission of a contraceptive method , as would be, breakage or malfunction of a condom , forget a power a sequential oral contraceptive with a maximum acceptable delay of the last shot , IUD expulsion , displacement or loss of a vaginal contraceptive diaphragm or a layer of gel or jelly , withdrawal ( untimely ) , misuse of vaginal spermicides , also after sexual intercourse during the fertile period theoretically , where the preventive method is the rhythm or periodic abstinence ( method temperatures ) .

Medication name: SILOGIN
Patent Medicines: GLANIQUE
Active substance: Levonorgestrel 0.75MG
Presentation: TABLETAS
Concentration: 2TAB 0.75MG
Lab: DIBA.S.A.
Box with 2TAB 0.075MG
Made in MEXICO